Somatic mutation plays a key role in transforming normal cells into cancerous cells. The analysis of cancer progression therefore requires the study of how point mutations and chromosomal mutations accumulate in cellular lineages. The spread of somatic mutations depends on the mutation rate, the number of cell divisions in the history of a cellular lineage, and the nature of competition between different cellular lineages. We consider how various aspects of tissue architecture and cellular competition affect the pace of mutation accumulation. (...) We also discuss the rise and fall of somatic mutation rates during cancer progression. BioEssays 26:291–299, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This chapter proposed a novel design methodology called Value-Sensitive Design and its potential application to the field of artificial intelligence research and design. It discusses the imperatives in adopting a design philosophy that embeds values into the design of artificial agents at the early stages of AI development. Because of the high risk stakes in the unmitigated design of artificial agents, this chapter proposes that even though VSD may turn out to be a less-than-optimal design methodology, it currently provides a (...) framework that has the potential to embed stakeholder values and incorporate current design methods. The reader should begin to take away the importance of a proactive design approach to intelligent agents. (shrink)

The purpose of this article is to explore some of the non-obvious characteristics of the social science research-social policy (SSRSP) paradigm. We examine some of the underlying assumptions of the readily accepted claim that social science research can lead to the creation of rational social policy. We begin by using the framework of meta-analysis as one of the most powerful means of informing policy by way of empirical research findings. This approach is critiqued and found wanting in several ways. Several (...) conceptual and definitional issues connected to the term “policy” are explored as well. A central argument is that even the best social science research is no guarantee of enlightened policymaking because the very (inductive) basis of empirical research militates against the possibility of going from research findings to policy. This claim is explored within the context of a central paradox. This paradox is explored in some depth. Finally, within the SSRSP claim, we analyze related issues such as the possibility of utilizing Mixed Methods and the politics of policymaking. We conclude that the SSRSP framework is, at best, a subjective one which ironically is needed, but one which is constrained by the very methods that is uses to formulate policy. (shrink)

This article examines deception possibilities for two players in simple three-person voting games. An example of one game vulnerable to (tacit) deception by two players is given and its implications discussed. The most unexpected findings of this study is that in those games vulnerable to deception by two players, the optimal strategy of one of them is always to announce his (true) preference order. Moreover, since the player whose optimal announcement is his true one is unable to induce a better (...) outcome for himself by misrepresenting his preference, while his partner can, this player will find that possessing a monopoly of information will not give him any special advantage. In fact, this analysis demonstrates that he may have incentives to share his information selectively with one or another of his opponents should he alone possess complete information at the outset. (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

Previous research has shown that emotionally-valenced words are given higher judgements of learning (JOLs) than are neutral words. The current study examined potential explanations for this emotional salience effect on JOLs. Experiment 1 replicated the basic emotionality/JOL effect. In Experiments 2A and 2B, we used pre-study JOLs and assessed memory beliefs qualitatively, finding that, on average, participants believed that positive and negative words were more memorable than neutral words. Experiment 3 utilised a lexical decision task, resulting in lower reaction times (...) (RTs) for positive words than for neutral words, but equivalent RTs for negative and neutral words, suggesting that processing fluency may partially account for higher JOLs for positive words, but not for negative words. Finally, we conducted a series of moderation analyses in Experiment 4 which assessed the relative contributions of fluency and beliefs to JOLs by measuring both factors in the same participants, showing that RTs made no significant contribution to JOLs for either positive or negative words. Our findings suggest that although positive words may be more fluently processed than neutral words, memory beliefs are the primary factor underlying higher JOLs for both positive and negative words. (shrink)

Judgements of the value or likelihood of a focal object or outcome have been shown to vary dramatically as a function of whether judgement is based on selective or comparative processing. This article explores the question of when selective versus comparative processing is likely, and demonstrates that as motivation and opportunity to process information carefully (operationalised as accountability and time pressure, respectively) decrease, the likelihood of selective processing increases. Moreover, we document how individuals manage to render judgements when in selective (...) processing mode by relying on categorical knowledge. (shrink)

This book attempts to explicate and expand upon Frank Ramsey's notion of the realistic spirit. In so doing, it provides a systematic reading of his work, and demonstrates the extent of Ramsey's genius as evinced by both his responses to the Tractatus Logico-Philosophicus , and the impact he had on Wittgenstein's later philosophical insights.

Standard philosophical explanations of the concept of knowledge invoke a personal goal of having true beliefs, and explain the other requirements for knowledge as indicating the best way to achieve that goal. In this highly original book, Steven L. Reynolds argues instead that the concept of knowledge functions to express a naturally developing kind of social control, a complex social norm, and that the main purpose of our practice of saying and thinking that people 'know' is to improve our (...) system for exchanging information, which is testimony. He makes illuminating comparisons of the knowledge norm of testimony with other complex social norms - such as those requiring proper clothing, respectful conversation, and the complementary virtues of tact and frankness - and shows how this account fits with our concept of knowledge as studied in recent analytic epistemology. His book will interest a range of readers in epistemology, psychology, and sociology. (shrink)

In what is advertised as a “controversial coast to coast bestseller,” most men who were asked “How would you feel if something about you were described as feminine or womanly?” said they’d be angry. Consider these voices from The Hite Report on Male Sexuality:Enraged. Insulted. Never mind what women are really like—I know what he’s saying: he’s saying I should be submissive to him.To be called “like a woman” by another man is to be humiliated by him, because most men (...) consider women to be weak, and a man doesn’t want to be considered weak.Chagrined. I may appear soft, but I carry a big stick. So watch out.If I was described as having something “like a woman’s,” I would be outraged. I would defend my masculinity almost automatically. I wouldn’t like being compared to a woman’s anything.1About two seconds of reflection should be enough to convince most of us that what is offered in The Hite Report on Male Sexuality as the representative testimony of contemporary American men is, in fact, representative: our relations with women are problematic, those with ourselves something worse. What Shere Hite does not call attention to is an intriguing recurrence in many of the responses: the question is heard as a charge and it is imagined to be coming from another male. The basic point now seems to me inescapable, though to say “inescapable” is in no way to say that the history of literary theory and criticism has found it so . One way of understanding that history is to read it as a series of ingenious escapes from the basic point which is economic and sexual and which goes something like this: What we know as “femininity” is internally linked to what we know as “masculinity” because both designations are highly motivated cultural constructions of biological difference that do powerful social work at the moment when they are lived, when they constitute the barely conscious and barely reflected upon substance of belief. The political synonym for “belief” is “ideology” in the particular sense of “ideology” as a constructed thing which nevertheless feels natural and is never experienced as a thing bearing interested human intention. The basic ideological point has to do with social engenderment, and it means, among other things, if you’re male, that you must police yourself for traces of femininity. If you’re male it means, among other things, that the great dread is not so much that another man might call you feminine or womanly , but that you might have to call yourself feminine or womanly. The political issue of gender has recently been the special concern of feminist criticism and eventually, after a long look at Wallace Stevens, I’ll address feminism directly, in what may be its institutionally most potent form. 1. Shere Hite, The Hite Report on Male Sexuality , p. 64. Frank Lentricchia is professor of English at Duke University. This essay is part of a forthcoming book, Ariel and the Police: Michel Foucault, William James, Wallace Stevens. He has also published Criticism and Social Change and After the new Criticism. (shrink)

The say-on-pay regulation in the Dodd-Frank Act requires publicly-traded U.S. firms to hold a nonbinding, advisory shareholder vote on executive compensation. Advocates claim that SOP voting gives shareholders a mechanism to hold managers and boards more accountable. Critics contend that SOP votes may simplistically reflect shareholders’ reactions to the overall value of CEO compensation or the firm’s net income. However, based on prior research, we contend that market participants’ SOP votes are likely to consider current income attributes. For example, (...) the market punishes firms that do not meet or beat benchmarks such as analyst earnings expectations, and that shareholders scrutinize the quality of the income sources of firms that consistently meet/beat analyst expectations. We thus expect that more shareholders will provide ‘agree’ SOP votes for a firm that consistently meets/beats analyst forecasts and does so when net income does not include nonrecurring gains. Further, we consider whether perceptions about the fairness of CEO compensation play a mediating role in the relationship between the interaction of these two current income attributes and SOP votes. Results from an experiment using evening MBA students as participants indicates that the two current income attributes significantly interact with respect to the percentage of agree SOP votes, and that compensation fairness perceptions fully mediate this relationship. Further, the mediating effect of compensation fairness perceptions is robust to including CEO-level and other determinants found in prior research. We conclude with a discussion of our findings and their implications for public policy and research. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Steven Fuller A FRENCH SCIENCE (WITH ENGLISH SUBTITLES) It is of no news to anyone with even a passing interest in the theoretical wranglings of literary critics that deconstruction is on the defensive. This is of special interest to an historian and philosopher of science such as myself because (with the notable exception of Frank Lentricchia's revisionist history of contemporary critical trends) ] most of the recent (...) salvos launched against deconstruction have been supplied by analytic philosophy.2 Indeed, some analytic philosophers have felt bold enough to enter the fray themselves. And as with other Anglo-American incursions into theoretical debates of continental origin, whatever is lost in subtlety and sheer ingenuity is made up for in clarity and commonsense. If there is one theme common to adi analytically inspired attacks on deconstruction, it is that critical method ought to be a systematic articulation of the intuitions of the average reflective reader. To be a literary critic is not to achieve esoteric insight into the uncommunicative nature of texts; rather, it is to become more fully aware of the many ways in which texts do communicate. While such advice may be reassuring, it is certainly not very "philosophical" in the sense of "deeply problematic" that deconstructionists would claim for the nature of texts. And the deconstructionists are right — so I believe. At least, I will try to show that the case for deconstruction, in all its radicalness, can be made with something of the clarity desired by analytic philosophers. A contentious critic might wonder, at this point, why the deconstructionists were not clear in the first place (thereby rendering this article superfluous). The reason, contrary to what certain "friends of deconstruction" in the analytic tradition would have us believe, is that there are few precedents in the recent history of philosophy for claims made by deconstructionists.3 It would indeed be faint praise to find, as Hacking and Rorty have maintained, that the theses of Barthes, Foucault, and Derrida were anticipated in the limpid prose style of a Quine, a Goodman, or a Kuhn.4 Why is the latter set of writers so clear, while the former set is so obscure? Our contentious critic might conclude diat clarity of style reflects a clarity of thought, and likewise for obscurity of style. In any case, both friends 2 Philosophy and Literature and foes of deconstruction tend to agree diat whatever is of value in the French texts may be derived with less effort by reading the American ones. The friends want to place deconstruction among several strains oftwentieth-century thought that would dissolve classical philosophy into a critical history of ideas, while the foes (more ingenuously perhaps) want to resume the business of practical criticism as usual and its attendant function (à la F. R. Leavis) of preserving Western Culture. Since the analytic devil can (and will) cite deconstructionist scripture for his own purposes, it is not clear that explicating Derrida will settle matters, especially since deconstruction gives an ironic twist to the search for what an author "had in mind" when he composed a particular text. It is, however, interesting to note that when one analytic philosopher recently presented a paradigm of literary criticism that allegedly compensated for the excesses of deconstruction, he resorted to Kantian talk about the intentions of the author being a "regulative ideal" toward which all responsible practical criticism aspires.5 This paradigm claims to owe to deconstruction the idea that, once an author is separated from his text, die reader becomes unable to verify any hypotheses about what the author meant by what he wrote. However, the evidence surrounding the text's composition (as well as the text itself) may be reconstructed so as to suggest a model of the audioes intentions. In that case, the explanatory adequacy of such a model would be relative to the evidence and methods available to the critic. And so, while the text certainly had a real audior who possessed a set of determinate intentions at the time ofwriting, mere is no reason to think that the most plausible model of the currendy available evidence picks out those intentions. What we have here is the first of two species of... (shrink)

The Space Act of 1958 begins, “The Congress hereby declares that it is the policy of the United States that activities in space should be devoted to peaceful purposes for the benefit of all mankind.” In March 1982, a Defense Department official commented on the statute: “We interpret the right to use space for peaceful purposes to include military uses of space to promote peace in the world.”1 The absurdity of this willful misinterpretation amazed me on first reading, and months (...) later it readily came to mind when I was looking for an effective way to illustrate the politics of interpretation. With just the right touch of moral indignation, I offered my literary criticism class this example of militaristic ideology blatantly misreading an antimilitaristic text.“But … the Defense Department is right!” objected the first student to speak. Somewhat amused, I spent the next ten minutes trying, with decreasing amusement, to show this student that the Reagan administration’s reading was clearly, obviously, painfully wrong. I pointed to the text. I cited the traditional interpretation. I noted the class consensus, which supported me. All to no avail. It was at this point that I felt that “theoretical urge”: the overwhelming desire for a hermeneutic account to which I could appeal to prove my student wrong. What I wanted was a general theory of interpretation that could supply rules outlawing my student’s misreading.This little hermeneutic fable introduces the three topics of my essay. One topic is the theoretical moment that concludes the narrative; another is the simple plot, a brief rhetorical exchange; and finally there’s the institutional setting in which the exchange takes place. These three topics preoccupy the sections that follow. Section 1 analyzes the problems resulting from the theoretical urge, the impasse of contemporary critical theory. Section 2 proposes my solution to this impasse, a solution I call rhetorical hermeneutics, which leads in section 3 to a rhetorical version of institutional history. 1. “National Aeronautics and Space Act of 1958,” United States Statutes at Large , vol. 72, pt. 1, sec. 102, p. 426; Robert Cooper, director of the Defense Advanced Research Projects Agency, quoted in Frank Greve, “Pentagon Research Retains Vision of ‘Winning’ N-war,” Miami Herald, 27 Mar. 1983, sec. D, p. 4. Steven Mailloux, associate professor of English at the University of Miami, is the author of Interpretive Conventions: the Reader in the Study of American Fiction. He is currently at work on a book tentatively entitled Rhetorical Power: Politics in American Literature, Criticism, and Theory. His previous contributions to Critical Inquiry are “Stanley Fish’s ‘Interpreting the Variorum’: Advance or Retreat?” and “Truth or Consequences: On Being Against Theory”. (shrink)

fl: Dad, what’s testeria?Dad: Figlio! What happened to your Italian? It’s TesaREEa! Capisce?fl: Yes.Dad: Tell me.fl: A store where they sell that stuff.Dad: In big jars!fl: Let’s go there! Frank Lentricchia is professor of English at Duke University. His latest book, Ariel and the Police: Michel Foucault, William James, Wallace Stevens, has just been published. He is also general editor of the Wisconsin Project on American Writers.

The beginning of the journey -- What this book is about : using ideas from mathematics, economics, and physics to tackle the big questions in philosophy : what is real? what can we know? what is the difference between right and wrong? and how should we live? -- Reality and unreality -- On what there is -- Why is there something instead of nothing? the best answer I have : mathematics exists because it must and everything else exists because it (...) is made of mathematics, with an excursion into artificial intelligence -- Unfinished business -- Unfinished business from chapter two : the nature and purpose of economic models -- How Richard Dawkins got it wrong -- Why Dawkins's argument against intelligent design can't be right and a mathematical analysis of the arguments for the existence of God -- Belief -- Daydream believers -- Most beliefs are ill-considered because most false beliefs are costless to hold -- The next several chapters will explore the consequences of this observation before we return to the question of where our beliefs and knowledge come from -- Unfinished business -- Unfinished business from the preceding chapter : how color vision works, sound, and water waves, the sheer craziness of economic protectionism -- Do believers believe? -- Our ill-considered beliefs about religion : why I believe that almost nobody is deeply religious -- On what there obviously is -- Our ill-considered beliefs about free will, ESP, and life after death -- Diogenes's nightmare -- How is legitimate disagreement possible if you're arguing with someone who is as intelligent and informed as you are, shouldn't you put just as much weight on your opponent's arguments as your own? -- The fact that we persist in disagreeing is strong evidence that we don't really care what's true -- Knowledge -- Knowing your math -- Where mathematical knowledge comes from and logic and why evidence and logic are not enough -- Unfinished business -- Unfinished business from the preceding chapter : the tale of hercules and the hydra, with an excursion into the lore of very large numbers -- Incomplete thinking -- Godel's incompleteness theorem and what it doesn't say about the limits of human knowledge -- The rules of logic and the tale of a Potbellied pig -- The power of logical thought, with excursions into the most counterintuitive theorem in all of mathematics and the tale of a potbellied pig -- The rules of evidence -- What we can and can't learn from evidence, with excursions into the value of preschool and how internet porn prevents rape -- The limits to knowledge -- What physics does and doesn't tell us about what we can and cannot know -- Understanding Heisenberg's uncertainty principle -- Unfinished business -- The oddness of the quantum world and why it matters to game theorists -- Right and wrong -- Telling right from wrong -- Some hard questions about right and wrong and about life and death -- The economist's golden rule -- A rule of thumb for good behavior -- How to be socially responsible -- Putting the rule of thumb into practice -- On not being a jerk -- Goofus and gallant on immigration policy -- The economist on the playground -- Our ill-considered beliefs about fairness in the market place and in the voting booth, contrasted with our carefully considered beliefs about fairness on the playground -- Unfinished business -- How ancient talmudic scholars anticipated modern economic theory -- The life of the mind -- How to think -- Some basic rules for clear thinking, mostly about economics, but also about arithmetic, neurobiology, sin, and eschewing blather -- What to study -- Advice to college students : stay away from the English department and approach the philosophy department with caution, with an excursion into the remarkable life of Frank Ramsey. (shrink)

No volume by single scholar can recreate the incessant dialectic of contemporary philosophic inquiry; hence we are offering a series that is a collaboration of many hands. The present series is intended to provide students, teachers, and interested nonprofessionals with collections of essays in every major problem area of contemporary philosophy. Each volume is devoted to a single set of interconnected issues; each issue is currently that subject of intense philosophic discussion. In making relatively inaccessible essays available, this series will (...) enable teachers of philosophy to find strategic or supplementary materials for a wide range of courses. To the student it offers the luxury of possessing essays formerly buried in bound journals or closeted in library reserves. To readers other than teachers and students, the series offers an opportunity to explore contemporary philosophy at first hand. To all readers, it offers original formulations of new ideas and fresh insight into topics of ancient ancestry. -Introduction / Frank A. Tillman. (shrink)

Richard Rorty is one of the principal architects of a new way of thinking about liberalism. He calls his way “liberal ironism”: it is a postmodern liberalism, without Enlightenment rationalism, without the hopeless and finally enervating aspiration to discover an a historical philosophical foundation for liberal principles and practices. The postmodern liberal ironist, unlike the classical liberal rationalist, “faces up to the contingency of his or her own most central beliefs and desires,” says Rorty, including the characteristic liberal belief that (...) “cruelty is the worst thing we do.” Such postmodern liberals frankly admit the apparently unhappy consequence of that essential “contingency,” that “there is no neutral, noncircular way to defend” liberal ways, no good argument to deploy against “Nazi and Marxist enemies of liberalism”; but no such argument is needed, says Rorty, since loyalty to one's own community is morality enough, even where that loyalty is without foundation. Here, I begin with a few words about Rorty's postmodern liberalism, as preface to a discussion of the effects of postmodern doctrines on liberal moral psychology. (shrink)

"Amongst the human mind's proudest accomplishments is the invention of a science dedicated to understanding itself: cognitive science. ... This volume is an authoritative guide to this exhilarating new body of knowledge, written by the experts, edited with skill and good judment. If we were to leave a time capsule for the next millennium with records of the great achievements of civilization, this volume would have to be in it."--Steven Pinker.

If, as many historians and theorists now believe, narrative is the form proper to historical explanation, this raises the problem of the terms in which such narratives are to be evaluated. Without a clear account of evaluation, the status of historical knowledge remains obscure. Beginning with the view, found in Hayden White and others, that historical narrative constitutes a meaning not reducible to the factual content it engages, this essay argues that such meaning can arise only through a synthesis of (...) cognitive and normative discourses. Narrative combines "heterogeneous" language games in such a way that neither appeal to "truth content" nor to "justice" suffices to decide the question of which of two competing historical explanations is, as a whole, superior. Examining in critical detail the opposed positions on this issue articulated by two recent theorists-Frank Ankersmit and David Carr -the paper concludes that the debate between those who hold that historical narratives should be judged in essentially cognitive terms and those who hold that they should be judged in essentially political terms cannot be resolved and that a philosophical view of historical narrative that is neither realist nor idealist needs to be developed. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Communities of Musical Practice by Ailbhe KennyFrank HeuserAilbhe Kenny Communities of Musical Practice ( New York: Routledge, 2016)When struggling in the confines of a practice room to overcome a technical difficulty on an instrument or explore different ways to shape a phrase, music learning can be a solitary and seemingly lonely enterprise. In such settings it is easy to assume that personal effort is the primary contributor to (...) an individual's musical expertise. Cognitive scientists steven sloman and Philip Fernbach1 argue against this view of human learning and suggest that much of what we know and accomplish results from working and living with others in a rich community of socially generated knowledge rather than by relying only on own efforts. This implies that the ability to develop sophisticated understandings in a discipline depends more on working collectively with others with whom we can share the labors of our cognitive efforts than on individual processes. This lends credence to the concept of learning in "communities of practice" that emerged during the 1990s.2Researchers have embraced this concept in music education and investigated the learning and relationships that develop in musical communities. June Countryman3 and N. Whitaker4 both examined how such communities impact learners in school-based music instructional settings. Deborah V. Blair developed [End Page 214] a professional development program for novice music educators that evolved into a community of practice.5 such communities offer members a place for identity formation and facilitate the acquisition of new knowledge in the discipline that is refined through active participation in meaningful learning experiences. In her book, Communities of Musical Practice, Ailbhe Kenny examines three music learning communities based in Limerick, Ireland and develops a model for community of practice that is specific to musical settings. This model can inform researchers investigating the fields of music education and community music. although it was not designed as a study in music education philosophy, the book is an example of excellent philosophical practices. as Wayne Bowman and ana Lucia Frega have suggested, if philosophy seeks to make "action more intelligent, more informed, more congruent with responsibly held beliefs,"6 Communities of Musical Practice offers a case study of the kind of reflective thinking that is central to philosophical practice. It is an example of how applying a reflective process to research data might provide the profession with both practical and philosophical insights.The book consists of seven chapters which are divided into three major sections. Part I, a Place for Communities of Musical Practice, defines communities of musical practice and describes the methodologies employed in the study. Part II, Illustrations of Communities of Musical Practices, offers case studies of three communities of musical practice that provide readers with examples of how the paradigm can be applied to investigate contrasting settings. Part III, Insights from Communities of Musical Practice, which summarizes the communities of musical practice framework, presents a model of how collective knowledge through common experiences contributes to senses of belonging, identity, and meaning-making and offers suggestions for nurturing these communities and developing policies that might contribute to increasing group music-making opportunities in communities. Following a review of these chapters, examples are given of how philosophical insights might be derived from this type of research.The central research question informing the work presented in the book is: How are communities of musical practice developed and sustained in practice?"7 This fundamental issue is refined through a series of sub-questions relating to the actual practices taking place within these communities of musical practices, the variety of relationships, actions, behaviors and experiences that are present within them, and the ways musical identities are created within and informed through participation in them. In Part I, Kenny develops a theoretical framework for examining communities of music practice by drawing from philosophy of practice, socio-cultural studies, and research in both education and music education which is based primarily on the writings of Bourdieu, Blacking, and Wenger. In particular, she employs etienne Wenger's framework of mutual engagement, [End Page 215] joint enterprise, and shared repertoire (or practices)8 as a scaffold to analyze and interpret "'situated' and collaborative musical... (shrink)

This paper provides a game-theoretic analysis of contrastive focus, extending insights from recent work on the role of noisy communication in prosodic accent placement to account for focus within sentences, sub-sentential phrases and words. The shared insight behind these models is that languages with prosodic focus marking assign prosodic prominence only within elements which constitute material critical for successful interpretation. We first take care to distinguish the information-structural notion of focus from an ontologically distinct notion of givenness marking, and then (...) outline the core properties of focus. We then introduce a signaling game between a speaker and hearer in which the goal is to transmit semantic content with the smallest signal possible. We apply the Iterated Best Response method of Franke to find equilibrium strategies in this game, where a unique equilibrium strategy in this case picks out the “critical information” of an utterance, which by hypothesis constitutes its focus. We show that iterating this game at different syntactic levels of a sentence makes correct predictions about the role of contrast in determining stress within words and phrases, and can be extended to account for association and second occurrence focus effects. (shrink)

In this memorial essay on Sir Frank Kermode (1919–2010), the author focuses on his own exchange of views with Kermode during the 1970s. In Kermode's book The Sense of an Ending (1966), he had criticized Frank's essay “Spatial Form in Modern Literature” (1945) as part of a larger critique of what the Romantic-Symbolist tradition of English poetry had become in the twentieth century. Yeats, Pound, Eliot, and other late Symbolists had turned artists into advocates of an irrational wisdom (...) superior to reason and common sense, thus isolating—so Kermode argued—the world of art from that of ordinary human concerns. Rejecting their view of art, he turned instead to a pre-Romantic tradition (including Spenser and Milton) that the Symbolists had rejected. Among modern writers, Kermode turned to Wallace Stevens, who became his foil for Yeats, Eliot, and Pound, as well as the most important influence on his own later thinking. Joseph Frank, in this essay, recalls the combination of acerbic intelligence, social concern, gentility, and finally friendship that characterized his debate over these questions with Kermode. Frank recalls as an indication of his respect and admiration for Kermode that he wrote, in 1977, that, even if his own theory of spatial form were to be shown worthless, it would still have value in having provided some of the stimulus for Kermode to write The Sense of an Ending. (shrink)

In this article, the author describes some of his own experiences of becoming an organizational systems theorist. The article also presents overviews of various systems theories that influenced the learning process from subject exploration to mastery. These include system dynamics, management systems, General Systems Theory, self-organizing systems, and autognomics. Additionally, discussions of system failures, philosophical pragmatism, and knowledge management all relate to their influence on systems theories. The article culminates with an examination of the possible causes of system failures and (...) proposes various new ideas for intervening in several large-scale issues, such as sustainability. Finally, there is a review of a new type of organizational performance measurement system known as the adaptive scorecard. (shrink)

The capacity to engage in systems thinking is often viewed as being a product of being able to understand complex systems due to one's facility in mastering systems theories, methods, and being able to adeptly reason. Relatively little attention is paid in the systems literature to the processes of learning from experience and creating knowledge as a direct consequence of individuals engaging systems thinking itself over time. In fact, the potential efficacy of systems thinking to improve performance normally seen as (...) only contingent on a priori knowledge, rather than knowledge created via learning from experience. Such newly create knowledge often results from engaging in modeling efforts and systemic forms of inquiry. This article proposes a model for creating new knowledge by coupling systems modeling with a pragmatic approach to knowledge-creation. This approach is based on a foundation of the pragmatic concepts first proposed by the American philosopher/scientist Charles Sanders Peirce over a century ago. This model offers systems practitioners a framework to engage in knowledge-intensive systems thinking (KIST) for addressing complex problematic issues. (shrink)

Abstract Context: Established in 1997, Summa Health System’s Medical Ethics Committee (EC) serves as an educational, supportive, and consultative resource to patients/families and providers, and serves to analyze, clarify, and ameliorate dilemmas in clinical care. In 2009 the EC conducted its 100th consult. In 2002 a Palliative Care Consult Service (PCCS) was established to provide supportive services for patients/families facing advanced illness; enhance clinical decision-making during crisis; and improve pain/symptom management. How these services affect one another has thus far been (...) unclear. Objectives: This study describes EC consults: types, reasons, recommendations and utilization, and investigates the impact the PCCS may have on EC consult requests or recommendations. Methods: Retrospective reviews of 100 EC records explored trends and changes in types of consults, reasons for consults, and EC recommendations and utilization. Results: There were 50 EC consults each in the 6 years pre- and post-PCCS. Differences found include: (1) a decrease in number of reasons for consult requests (133–62); (2) changes in top two reasons for EC consult requests from ‘Family opposed to withdrawing life-sustaining treatment (LST)’ and ‘Patient capacity in question’ to ‘Futility’ and ‘Physician opposed to providing LST’; (3) changes in top two recommendations given by the EC from ‘Emotional Support for Patient/Family’ and ‘Initiate DNR Order’ to ‘Comfort Care’ and ‘Withdraw Treatment.’ Overall, 88% of recommendations were followed. Conclusion: PCCS availability and growth throughout the hospital may have influenced EC consult requests. EC consults regarding family opposition to withdrawing LST and EC recommendations for patient/family support declined. Content Type Journal Article Pages 1-16 DOI 10.1007/s10730-011-9170-9 Authors Jessica Richmond Moeller, Department of Psychiatry and Behavioral Sciences, Akron General Medical Center, 400 Wabash Ave, Akron, OH 44307, USA Teresa H. Albanese, Health Services Research and Education Institute, Summa Health System and Northeast Ohio Medical University, 55 Arch St., Suite 1A, Akron, OH 44304, USA Kimberly Garchar, Kent State University, 6000 Frank Ave., N.W, North Canton, OH 44720, USA Julie M. Aultman, Department of Family and Community Medicine, Northeast Ohio Medical University, P.O. Box 95, Rootstown, OH 44272, USA Steven Radwany, Palliative Care and Hospice Services, Summa Health System and Northeast Ohio Medical University, 55 Arch St., Suite 1A, Akron, OH 44304, USA Dean Frate, Internal Medicine, Palliative Care and Hospice Services, Summa Health System and Northeast Ohio Medical University, 55 Arch St., Suite 1A, Akron, OH 44304, USA Journal HEC Forum Online ISSN 1572-8498 Print ISSN 0956-2737. (shrink)

Distinctions have been proposed between systems of reasoning for centuries. This article distills properties shared by many of these distinctions and characterizes the resulting systems in light of recent findings and theoretical developments. One system is associative because its computations reflect similarity structure and relations of temporal contiguity. The other is "rule based" because it operates on symbolic structures that have logical content and variables and because its computations have the properties that are normally assigned to rules. The systems serve (...) complementary functions and can simultaneously generate different solutions to a reasoning problem. The rule-based system can suppress the associative system but not completely inhibit it. The article reviews evidence in favor of the distinction and its characterization. (shrink)

With armed conflict in the Persian Gulf now upon us, Harvard archaeologist Steven LeBlanc takes a long-term view of the nature and roots of war, presenting a controversial thesis: The notion of the "noble savage" living in peace with one another and in harmony with nature is a fantasy. In Constant Battles: The Myth of the Peaceful, Noble Savage , LeBlanc contends that warfare and violent conflict have existed throughout human history, and that humans have never lived in ecological (...) balance with nature. The start of the second major U.S. military action in the Persian Gulf, combined with regular headlines about spiraling environmental destruction, would tempt anyone to conclude that humankind is fast approaching a catastrophic end. But as LeBlanc brilliantly argues, the archaeological record shows that the warfare and ecological destruction we find today fit into patterns of human behavior that have gone on for millions of years. Constant Battles surveys human history in terms of social organization-from hunter gatherers, to tribal agriculturalists, to more complex societies. LeBlanc takes the reader on his own digs around the world -- from New Guinea to the Southwestern U.S. to Turkey -- to show how he has come to discover warfare everywhere at every time. His own fieldwork combined with his archaeological, ethnographic, and historical research, presents a riveting account of how, throughout human history, people always have outgrown the carrying capacity of their environment, which has led to war. Ultimately, though, LeBlanc's point of view is reassuring and optimistic. As he explains the roots of warfare in human history, he also demonstrates that warfare today has far less impact than it did in the past. He also argues that, as awareness of these patterns and the advantages of modern technology increase, so does our ability to avoid war in the future. (shrink)

Conceptual features differ in how mentally tranformable they are. A robin that does not eat is harder to imagine than a robin that does not chirp. We argue that features are immutable to the extent that they are central in a network of dependency relations. The immutability of a feature reflects how much the internal structure of a concept depends on that feature; i.e., how much the feature contributes to the concept's coherence. Complementarily, mutability reflects the aspects in which a (...) concept is flexible. We show that features can be reliably ordered according to their mutability using tasks that require people to conceive of objects missing a feature, and that mutability (conceptual centrality) can be distinguished from category centrality and from diagnosticity and salience. We test a model of mutability based on asymmetric, unlabeled, pairwise dependency relations. With no free parameters, the model provides reasonable fits to data. Qualitative tests of the model show that mutability judgments are unaffected by the type of dependency relation and that dependency structure influences judgments of variability. (shrink)

Cover -- Title -- Copyright -- Contents -- List of Abbreviations -- Introduction: 'We': The Dangerous Thing -- 1 The Sellarsian Ethical Framework -- 2 Josiah Royce's Philosophy of Loyalty -- 3 Richard Rorty's Quasi-Sellarsian We -- 4 On the Prospects of Redescribing Rorty Roycely -- Bibliography -- Index.

A normative framework for modeling causal and counterfactual reasoning has been proposed by Spirtes, Glymour, and Scheines. The framework takes as fundamental that reasoning from observation and intervention differ. Intervention includes actual manipulation as well as counterfactual manipulation of a model via thought. To represent intervention, Pearl employed the do operator that simplifies the structure of a causal model by disconnecting an intervened-on variable from its normal causes. Construing the do operator as a psychological function affords predictions about how people (...) reason when asked counterfactual questions about causal relations that we refer to as undoing, a family of effects that derive from the claim that intervened-on variables become independent of their normal causes. Six studies support the prediction for causal arguments but not consistently for parallel conditional ones. Two of the studies show that effects are treated as diagnostic when their values are observed but nondiagnostic when they are intervened on. These results cannot be explained by theories that do not distinguish interventions from other sorts of events. (shrink)

Entrepreneurs with social goals face various challenges; insights into how these entrepreneurs experience and appreciate their work remain a black box though. Drawing on identity, conservation of resources, and person–organization fit theories, this study examines how entrepreneurs’ social value creation beliefs relate to their work-related well-being (job satisfaction, work engagement, and lack of work burnout), as well as how this process might be influenced by social concerns with respect to the common good. Using data from the German Public Value Atlas (...) 2015 and 2019 and the Swiss Public Value Atlas 2017, a three-study design analyzes three samples of entrepreneurs in Germany and Switzerland. Study 1 reveals that entrepreneurs report higher job satisfaction when they believe their organization creates social value. Study 2 indicates that these beliefs relate negatively to work burnout; entrepreneurs’ perceptions of having meaningful work mediate this relationship. Study 3 affirms and extends these results by showing that a sense of work meaningfulness mediates the relationship between social value creation beliefs and work engagement and that this mediating role is more prominent among entrepreneurs with strong social concerns. This investigation thus identifies a critical pathway—the extent to which entrepreneurs experience their work activities as important and personally meaningful—that connects social value creation beliefs with enhanced work-related well-being, as well as how this process might vary with a personal orientation that embraces the common good. (shrink)

This study investigates the effect of country-level emancipative forces on corporate gender diversity around the world. Based on Welzel’s theory of emancipation, we develop an emancipatory framework of board gender diversity that explains how action resources, emancipative values and civic entitlements enable, motivate and encourage women to take leadership roles on corporate boards. Using a sample of 6390 firms operating in 30 countries around the world, our results show positive single and combined effects of the framework components on board gender (...) diversity. Our research adds to the existing literature in a twofold manner. First, our integrated framework offers a more encompassing, complete and theoretically richer picture of the key drivers of board gender diversity. Second, by testing the framework empirically, we extend the evidence on national drivers of board gender diversity. (shrink)

Topics in Cognitive Science, Volume 14, Issue 1, Page 31-44, January 2022.